HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

In vitro reversal of cardiac deterioration in septic shock with tetraethylammonium chloride.

Abstract
Overwhelming sepsis associated with cardiac failure continues to be a major clinical problem. This is commonly associated with a failure to respond to conventional pharmacologic therapy. This study was undertaken to see if manipulations of the electrophysiologic defects previously described by treatment with tetraethylammonium chloride (TEA) would be advantageous. Septic shock was induced in rabbits by a lethal dose of Escherichia coli. Peak tension and velocities of contraction and relaxation were measured in papillary muscle with and without 5mM TEA. Exposure to this compound improved peak tension and velocities of contraction and relaxation to normal values. The action of TEA is not specific to septic tissue as values in normal muscles are similarly improved. Tetraethylammonium chloride or other drugs that decrease outward potassium current and prolong the action potential duration may be helpful in treating cardiac dysfunction that accompanies sepsis.
AuthorsJ E DeMeules
JournalArchives of surgery (Chicago, Ill. : 1960) (Arch Surg) Vol. 121 Issue 1 Pg. 65-70 (Jan 1986) ISSN: 0004-0010 [Print] United States
PMID3510606 (Publication Type: Journal Article)
Chemical References
  • Tetraethylammonium Compounds
  • Tetraethylammonium
Topics
  • Action Potentials (drug effects)
  • Animals
  • Escherichia coli Infections (drug therapy, physiopathology)
  • In Vitro Techniques
  • Membrane Potentials (drug effects)
  • Muscle Contraction (drug effects)
  • Papillary Muscles (drug effects, physiopathology)
  • Rabbits
  • Shock, Septic (drug therapy, physiopathology)
  • Tetraethylammonium
  • Tetraethylammonium Compounds (pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: