Abstract |
204 individuals from a rural community were given a single dose of oxantel- pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug either as 15mg/kg bodyweight given twice in one day, with an interval of about 12 hours, or 20mg/kg bodyweight given daily for 2 days. Cure rates obtained were 100% in both groups for ascariasis; 89.2% of those given the first regimen were cured of trichuriasis compared with 71.2% of those on the second. For trichuriasis, oxantel- pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested.
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Authors | B D Cabrera, F S Sy |
Journal | Drugs
(Drugs)
Vol. 15 Suppl 1
Pg. 78-86
( 1978)
ISSN: 0012-6667 [Print] New Zealand |
PMID | 350570
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Drug Combinations
- Pyrimidines
- Soil
- Styrenes
- Pyrantel
|
Topics |
- Adolescent
- Adult
- Child
- Child, Preschool
- Clinical Trials as Topic
- Drug Administration Schedule
- Drug Combinations
- Feces
(parasitology)
- Female
- Helminthiasis
(drug therapy, epidemiology, parasitology)
- Humans
- Infant
- Male
- Middle Aged
- Philippines
- Pyrantel
(administration & dosage, therapeutic use)
- Pyrimidines
(therapeutic use)
- Rural Population
- Soil
- Styrenes
(therapeutic use)
- Urban Population
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