Oxantel-pyrantel in various regimens for the treatment of soil transmitted helminthiasis in rural and urban communities.

204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. From an urban community, 124 patients were given the same drug either as 15mg/kg bodyweight given twice in one day, with an interval of about 12 hours, or 20mg/kg bodyweight given daily for 2 days. Cure rates obtained were 100% in both groups for ascariasis; 89.2% of those given the first regimen were cured of trichuriasis compared with 71.2% of those on the second. For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested.
AuthorsB D Cabrera, F S Sy
JournalDrugs (Drugs) Vol. 15 Suppl 1 Pg. 78-86 ( 1978) ISSN: 0012-6667 [Print] SWITZERLAND
PMID350570 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Drug Combinations
  • Pyrimidines
  • Soil
  • Styrenes
  • Pyrantel
  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Drug Administration Schedule
  • Drug Combinations
  • Feces (parasitology)
  • Female
  • Helminthiasis (drug therapy, epidemiology, parasitology)
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Philippines
  • Pyrantel (administration & dosage, therapeutic use)
  • Pyrimidines (therapeutic use)
  • Rural Population
  • Soil
  • Styrenes (therapeutic use)
  • Urban Population

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