Abstract |
Tinidazole was given in a single dose of 2g a day for 2 days to 17 adults, and in a single dose of 50mg/kg bodyweight daily for 3 days to 4 children, with symptomatic, but not severe, intestinal amoebiasis. All 21 patients showed clinical improvement but only 20 (95%) were parasitologically cured as evinced by failure to demonstrate Entamoeba histolytica in 3 stool samples collected on the 4th, 15th and 22nd day after treatment. Two subjects had mild nausea within a few hours of taking the first dose, while 8 had constipation of 3 to 5 days duration after treatment. 1 patient had nausea and constipation and another had palpitations.
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Authors | E G Garcia |
Journal | Drugs
(Drugs)
Vol. 15 Suppl 1
Pg. 16-8
( 1978)
ISSN: 0012-6667 [Print] New Zealand |
PMID | 350562
(Publication Type: Clinical Trial, Journal Article)
|
Chemical References |
- Nitroimidazoles
- Tinidazole
|
Topics |
- Adult
- Child
- Clinical Trials as Topic
- Dysentery, Amebic
(drug therapy)
- Humans
- Nitroimidazoles
(therapeutic use)
- Tinidazole
(administration & dosage, adverse effects, therapeutic use)
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