Steroid-induced ocular hypertension in the rabbit: a model using subconjunctival injections.

Abstract

Topical application of glucocorticoids in rabbit eyes has been used extensively in the study of steroid-induced ocular hypertension. Herein, we report no difference in intraocular pressure (IOP) between rabbits treated with topically applied dexamethasone and those receiving a vehicle placebo. In order to develop an alternative model, we have studied the effects on IOP of three subconjunctivally injected steroids: betamethasone, cortisone, and triamcinolone. All three produced elevations in IOP above controls and the most consistent elevation was observed with triamcinolone. Previously, a wide range of changes in IOP have been regarded as significant in studies using the topical mode. Our findings suggest that subconjunctival injections of steroids in rabbits are a viable alternative to topical application and may prove to provide a more consistent and reproducible model for the study of steroid-induced ocular hypertension.

• Authors: D E Hester, P N Trites, R L Peiffer, V Petrow
• Journal: Journal of ocular pharmacology (J Ocul Pharmacol) Vol. 3 Issue 3 Pg. 185-9 ( 1987) ISSN: 8756-3320 [Print] United States
• PMID: 3503913 (Publication Type: Journal Article)

Chemical References

• Triamcinolone
• Dexamethasone
• Betamethasone
• Cortisone

Topics

• Animals
• Betamethasone (pharmacology)
• Conjunctiva
• Cortisone (pharmacology)
• Dexamethasone (pharmacology)
• Injections
• Intraocular Pressure (drug effects)
• Ocular Hypertension (chemically induced, physiopathology)
• Rabbits
• Time Factors
• Triamcinolone (pharmacology)