Abstract |
We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma. The mean fall in ocular tension with the combined therapy was 10.67 mmHg, and with adrenaline 1% 6.31 mmHg, 24 hours after the commencement of phasing. The combined drop produced satisfactory control of ocular tension in all cases. These results indicate that a combined drop of guanethidine 3% and adrenaline 0.5% is a promising topical therapy for the control of chronic open-angle glaucoma.
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Authors | K B Mills, A E Ridgway |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 62
Issue 5
Pg. 320-3
(May 1978)
ISSN: 0007-1161 [Print] England |
PMID | 350265
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drug Combinations
- Ophthalmic Solutions
- Epinephrine
- Guanethidine
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Topics |
- Aged
- Chronic Disease
- Clinical Trials as Topic
- Double-Blind Method
- Drug Combinations
- Epinephrine
(administration & dosage, therapeutic use)
- Female
- Glaucoma
(drug therapy)
- Guanethidine
(administration & dosage, therapeutic use)
- Humans
- Male
- Middle Aged
- Ophthalmic Solutions
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