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Circulating T-cell populations during mercuric chloride-induced nephritis in the Brown Norway rat.

Abstract
Fluorescence-activated cell sorter analysis was used to study the peripheral lymphocyte populations during mercuric chloride (HgCl2)-induced autoimmune nephritis in the Brown Norway (BN) rat. Sequential studies showed a transient loss of T cells from peripheral blood attributable to decreases in the percentage of T-helper cells. In addition, there was a decrease in the percentage of T-cytotoxic/suppressor cells prior to the appearance of circulating anti-GBM antibodies, followed by elevated levels of T-suppressor cells during down-regulation of the response. This method may allow closer inspection of the events linking changes in T-cell populations and induction and termination of an autoimmune response.
AuthorsC Bowman, C Green, L Borysiewicz, C M Lockwood
JournalImmunology (Immunology) Vol. 61 Issue 4 Pg. 515-20 (Aug 1987) ISSN: 0019-2805 [Print] ENGLAND
PMID3502119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Mercuric Chloride
Topics
  • Animals
  • Autoantibodies (analysis)
  • Autoimmune Diseases (immunology)
  • Basement Membrane (immunology)
  • Female
  • Glomerulonephritis (chemically induced, immunology)
  • Kidney Glomerulus (immunology)
  • Leukocyte Count
  • Mercuric Chloride
  • Rats
  • Rats, Inbred BN
  • T-Lymphocytes (classification)

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