Circulating T-cell populations during mercuric chloride-induced nephritis in the Brown Norway rat.

Fluorescence-activated cell sorter analysis was used to study the peripheral lymphocyte populations during mercuric chloride (HgCl2)-induced autoimmune nephritis in the Brown Norway (BN) rat. Sequential studies showed a transient loss of T cells from peripheral blood attributable to decreases in the percentage of T-helper cells. In addition, there was a decrease in the percentage of T-cytotoxic/suppressor cells prior to the appearance of circulating anti-GBM antibodies, followed by elevated levels of T-suppressor cells during down-regulation of the response. This method may allow closer inspection of the events linking changes in T-cell populations and induction and termination of an autoimmune response.
AuthorsC Bowman, C Green, L Borysiewicz, C M Lockwood
JournalImmunology (Immunology) Vol. 61 Issue 4 Pg. 515-20 (Aug 1987) ISSN: 0019-2805 [Print] ENGLAND
PMID3502119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Autoantibodies
  • Mercuric Chloride
  • Animals
  • Autoantibodies (analysis)
  • Autoimmune Diseases (immunology)
  • Basement Membrane (immunology)
  • Female
  • Glomerulonephritis (chemically induced, immunology)
  • Kidney Glomerulus (immunology)
  • Leukocyte Count
  • Mercuric Chloride
  • Rats
  • Rats, Inbred BN
  • T-Lymphocytes (classification)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: