Abstract |
We treated 20 steroid-resistant or steroid-dependent nephrotic patients with oral cyclosporin for 8 weeks; they had been treated previously with cyclophosphamide or chlorambucil. Cyclosporine was started at 7 mg/kg/d and titrated to maintain a serum level of 100 to 200 ng/mL. Of 20 patients, 14 had a complete remission and the remaining six had a reduction in their proteinuria. By life table analysis, 40% of the responders show a sustained remission of up to a year. Pretherapy levels of interleukin 2, measured in 10 patients, were normal or supranormal in eight, six of whom were treatment responders; two patients with low levels of interleukin 2 were both nonresponders. Cyclosporine can be used to induce a remission in relapsing nephrotic patients, and short-term cyclosporine therapy does not produce nephrotoxic effects.
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Authors | A Tejani, K Butt, H Trachtman, M Suthanthiran, C J Rosenthal, M R Khawar |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 111
Issue 6 Pt 2
Pg. 1056-62
(Dec 1987)
ISSN: 0022-3476 [Print] United States |
PMID | 3500297
(Publication Type: Journal Article)
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Chemical References |
- Cyclosporins
- Interleukin-2
- Steroids
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Topics |
- Adolescent
- Child
- Child, Preschool
- Cyclosporins
(therapeutic use)
- Drug Evaluation
- Drug Resistance
- Humans
- Interleukin-2
(analysis)
- Kidney
(pathology)
- Nephrotic Syndrome
(drug therapy, pathology)
- Recurrence
- Steroids
(therapeutic use)
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