Cyclosporine-induced remission of relapsing nephrotic syndrome in children.

Abstract

We treated 20 steroid-resistant or steroid-dependent nephrotic patients with oral cyclosporin for 8 weeks; they had been treated previously with cyclophosphamide or chlorambucil. Cyclosporine was started at 7 mg/kg/d and titrated to maintain a serum level of 100 to 200 ng/mL. Of 20 patients, 14 had a complete remission and the remaining six had a reduction in their proteinuria. By life table analysis, 40% of the responders show a sustained remission of up to a year. Pretherapy levels of interleukin 2, measured in 10 patients, were normal or supranormal in eight, six of whom were treatment responders; two patients with low levels of interleukin 2 were both nonresponders. Cyclosporine can be used to induce a remission in relapsing nephrotic patients, and short-term cyclosporine therapy does not produce nephrotoxic effects.

• Authors: A Tejani, K Butt, H Trachtman, M Suthanthiran, C J Rosenthal, M R Khawar
• Journal: The Journal of pediatrics (J Pediatr) Vol. 111 Issue 6 Pt 2 Pg. 1056-62 (Dec 1987) ISSN: 0022-3476 [Print] United States
• PMID: 3500297 (Publication Type: Journal Article)

Chemical References

• Cyclosporins
• Interleukin-2
• Steroids

Topics

• Adolescent
• Child
• Child, Preschool
• Cyclosporins (therapeutic use)
• Drug Evaluation
• Drug Resistance
• Humans
• Interleukin-2 (analysis)
• Kidney (pathology)
• Nephrotic Syndrome (drug therapy, pathology)
• Recurrence
• Steroids (therapeutic use)