Joint inflammation in mice induced by a MT4+ Lyt-2- T cell clone. Characteristics and the induction of flare-up reactions.

Abstract

Joint inflammations were induced in mice by cloned MT4+ Lyt-2- T cells specific for methylated bovine serum albumin. This was done either by intra-articular or by i.v. administration of the cloned T cells, together with local injection of the antigen. Local rechallenge with methylated bovine serum albumin several weeks after waning of the joint inflammation caused a flare-up reaction. The inflammations were quantified by a 99mTc-uptake method and examined histologically. The arthritis induced by the cloned T cells showed aspects of a delayed type hypersensitivity reaction characterized by an intense infiltrate which resembles the inflammation in the human rheumatoid joint. The data presented show that joint inflammations can be induced by T cells only and that, after waning, reexposition to the original antigen can induce a flare-up reaction. The data suggest a central role of T cells in the induction and the exacerbations observed in rheumatoid arthritis.

• Authors: I S Klasen, R M Ladestein, I G Donselaar, W B van den Berg, R Tees, R Benner
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 139 Issue 10 Pg. 3275-80 (Nov 15 1987) ISSN: 0022-1767 [Print] United States
• PMID: 3500213 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens
• methylated bovine serum albumin
• Serum Albumin, Bovine

Topics

• Animals
• Antigens (immunology)
• Arthritis, Rheumatoid (immunology, pathology)
• Clone Cells (immunology, transplantation)
• Disease Models, Animal
• Hypersensitivity, Delayed (immunology, pathology)
• Immunization, Passive
• Inflammation
• Mice
• Mice, Inbred C57BL
• Mice, Inbred Strains
• Mice, Nude
• Serum Albumin, Bovine (immunology)
• T-Lymphocytes (immunology, transplantation)