Bacampicillin and the immune response.

Abstract

To evaluate the possible influence of a bacampicillin on the immune response, 16 subjects, out of a group of 60 patients with bacterial respiratory tract infections, had various tests of immune function determined, before and after treatment. The peripheral mononuclear blastogenic index (ratio between PHA-induced and spontaneous proliferation), PHA-induced interferon-gamma production, percentages of T and B lymphocytes, serum immunoglobulins (IgG, IgM, IgA) levels, failed to show any significative differences before and after the treatment with bacampicillin. The PHA-induced interleukin-2 production increased after treatment but just failed to reach statistical significance (0.1 less than P less than 0.05; t = 1.9). The clinical condition of 56 of the sixty (93.3%) treated patients improved and neither side-effects nor alterations of liver or kidney function were observed. This study has shown no inhibitory effect of bacampicillin on the immune response while confirming its clinical efficacy.

• Authors: A Scordamaglia, G Ciprandi, S Mirabelli, R Aquilina, L Calcagno, A Nicolini, C Simonassi, M De Palma
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 19 Issue 6 Pg. 791-3 (Jun 1987) ISSN: 0305-7453 [Print] England
• PMID: 3497151 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-2
• Ampicillin
• bacampicillin

Topics

• Adolescent
• Adult
• Aged
• Ampicillin (analogs & derivatives, pharmacology)
• Female
• Humans
• Immunity (drug effects)
• Interleukin-2 (biosynthesis)
• Lymphocyte Activation (drug effects)
• Male
• Middle Aged