Thymic hypoplasia associated with isotretinoin embryopathy.

Abstract	A newborn had isotretinoin embryopathy, including thymic hypoplasia. Evaluation of her immune functions demonstrated progressive attrition of T cells over the nine weeks until her death due to pneumonia. These studies strongly suggest an insult by isotretinoin to the immune system. Immune abnormalities may predispose infants with isotretinoin embryopathy to infection and contribute to their high mortality.
Authors	M Cohen, A Rubinstein, J K Li, G Nathenson
Journal	American journal of diseases of children (1960) (Am J Dis Child) Vol. 141 Issue 3 Pg. 263-6 (Mar 1987) ISSN: 0002-922X [Print] United States
PMID	3492909 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Tretinoin Isotretinoin
Topics	Abnormalities, Drug-Induced (etiology) Adult Facial Bones (abnormalities) Female Humans Infant, Newborn Isotretinoin Leukocyte Count Maternal-Fetal Exchange Pregnancy Skull (abnormalities) T-Lymphocytes Thymus Gland (abnormalities, immunology) Tretinoin (adverse effects)

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