Pharmacological study of the new mucolytic drug N-guanyl-cysteine.

The pharmacological evaluation of N-guanyl-cysteine (IQB-782) is reported. This new cysteine derivative shows a potent mucolytic-expectorant activity in different test systems. Thus, IQB-782 protects rats against tobacco-smoke-induced respiratory airway obstruction, increases the tracheo-bronchial mucus secretion in rabbits and increases the pulmonary excretion of fluorescein in mice, an index of broncho-secretagogue activity. Like other mucolytics, IQB-782 is also effective in vitro in reducing the viscosity of a suspension of gastric mucin. This new drug is apparently devoid of any cardiovascular or autonomic activity and shows a moderate CNS depressant effect. IQB-782 is consequently a new thiol derivative which may offer some advantages in the treatment of different types of obstructive pulmonary disease.
AuthorsR Moratalla, R Romera, A Galiano
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 6 Pg. 918-23 (Jun 1986) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID3488747 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Expectorants
  • N-guanylcysteine
  • Cysteine
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticonvulsants
  • Bronchitis (etiology, physiopathology)
  • Cysteine (analogs & derivatives, pharmacology)
  • Expectorants (pharmacology)
  • Guinea Pigs
  • Hemodynamics (drug effects)
  • Male
  • Mice
  • Mice, Inbred ICR
  • Psychomotor Performance (drug effects)
  • Rabbits
  • Rats
  • Rats, Inbred Strains
  • Sleep (drug effects)
  • Viscosity

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