Pharmacological study of the new mucolytic drug N-guanyl-cysteine.

Abstract

The pharmacological evaluation of N-guanyl-cysteine (IQB-782) is reported. This new cysteine derivative shows a potent mucolytic-expectorant activity in different test systems. Thus, IQB-782 protects rats against tobacco-smoke-induced respiratory airway obstruction, increases the tracheo-bronchial mucus secretion in rabbits and increases the pulmonary excretion of fluorescein in mice, an index of broncho-secretagogue activity. Like other mucolytics, IQB-782 is also effective in vitro in reducing the viscosity of a suspension of gastric mucin. This new drug is apparently devoid of any cardiovascular or autonomic activity and shows a moderate CNS depressant effect. IQB-782 is consequently a new thiol derivative which may offer some advantages in the treatment of different types of obstructive pulmonary disease.

• Authors: R Moratalla, R Romera, A Galiano
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 36 Issue 6 Pg. 918-23 (Jun 1986) ISSN: 0004-4172 [Print] GERMANY, WEST
• PMID: 3488747 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Anticonvulsants
• Expectorants
• N-guanylcysteine
• Cysteine

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal
• Anticonvulsants
• Bronchitis (etiology, physiopathology)
• Cysteine (analogs & derivatives, pharmacology)
• Expectorants (pharmacology)
• Guinea Pigs
• Hemodynamics (drug effects)
• Male
• Mice
• Mice, Inbred ICR
• Psychomotor Performance (drug effects)
• Rabbits
• Rats
• Rats, Inbred Strains
• Sleep (drug effects)
• Viscosity