Histologic analysis of tissue response to bucrylate-pantopaque mixture.

Abstract

A toxicologic-pathologic study of isobutyl-2-cyanoacrylate (Bucrylate) was carried out first in dogs and then in humans whose arteriovenous malformations were infused with this embolic agent. The canine specimens obtained at 7, 18, 28, and 147 days after embolization showed the development of a mild histiocytic giant cell reaction, which evolved to end-state sclerotic arteritis. The response was confined to the vessels and did not involve contiguous parenchymal tissues. Ten human specimens, obtained from 1 hr to 7 years after treatment, showed a similar bland reaction with no evidence of suppuration or premalignant changes.

• Authors: L D Cromwell, P C Freeny, C W Kerber, L L Kunz, A B Harris, C M Shaw
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 147 Issue 3 Pg. 627-31 (Sep 1986) ISSN: 0361-803X [Print] United States
• PMID: 3488665 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cyanoacrylates
• Iodobenzenes
• Bucrylate
• Iophendylate

Topics

• Adolescent
• Adult
• Animals
• Arteries (drug effects, pathology)
• Brain (drug effects, pathology)
• Bucrylate (administration & dosage, pharmacology)
• Cerebral Arteries (drug effects, pathology)
• Cyanoacrylates (pharmacology)
• Dogs
• Embolization, Therapeutic
• Female
• Humans
• Intracranial Arteriovenous Malformations (pathology, therapy)
• Iodobenzenes (pharmacology)
• Iophendylate (administration & dosage, pharmacology)
• Male
• Middle Aged
• Renal Artery (drug effects, pathology)
• Time Factors