Dynamic spin-echo MRI of liver cancer using Gadolinium-DTPA: animal investigation.

Abstract

An animal model of liver cancer was used to demonstrate that with a fast MRI technique, Gadolinium-DTPA increases tumor-liver contrast. A spin-echo pulse sequence with short repetition (TR) and echo-delay (TE) times (TR 250/TE 15/Excitations 1) has a scan time of 0.6 min, which allows early dynamic postcontrast infusion imaging. This is necessary to capture peak compartmental differences when an extracellular contrast agent such as Gadolinium-DTPA is used. This short TR/short TE pulse sequence also increases T1-dependent tissue contrast over the traditional (inversion recovery or spin echo) T1-weighted pulse sequences. Our studies suggest a significant potential for improved detection of liver metastases with Gadolinium-DTPA-enhanced liver MRI.

• Authors: S Saini, D D Stark, T J Brady, J Wittenberg, J T Ferrucci Jr
• Journal: AJR. American journal of roentgenology (AJR Am J Roentgenol) Vol. 147 Issue 2 Pg. 357-62 (Aug 1986) ISSN: 0361-803X [Print] United States
• PMID: 3487953 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Pentetic Acid

Topics

• Adenocarcinoma (diagnosis, secondary)
• Animals
• Contrast Media
• Female
• Liver Neoplasms (diagnosis, secondary)
• Magnetic Resonance Spectroscopy (methods)
• Mammary Neoplasms, Experimental (diagnosis)
• Neoplasm Transplantation
• Pentetic Acid
• Rats
• Rats, Inbred F344