Human urinary megakaryocyte colony-stimulating factor in thrombopoietic disorders.

Abstract

The level of urinary Meg-CSF activity in patients with various thrombopoietic disorders was studied. Five out of eight patients with idiopathic thrombocytopenic purpura had megakaryocytic hyperplasia in the marrow and increased Meg-CSF activity in the urine. Urinary Meg-CSF activity in patients with polycythaemia vera and essential thrombocythaemia was normal. There was a significant inverse correlation between urinary Meg-CSF activity and peripheral blood platelet count but not bone marrow megakaryocyte mass. There was a significant increase of urinary Meg-CSF activity during the period of thrombocytopenia after chemotherapy in patients with acute leukaemia who were in complete remission. The timing of maximal Meg-CSF levels corresponded to the nadirs of platelet counts. These results support the concept that Meg-CSF may play a significant role in the regulation of megakaryopoiesis and/or thrombopoiesis in vivo.

• Authors: M Kawakita, S Yamamoto, N Asou, M Ishii, M Sakaguchi, K Takatsuki
• Journal: British journal of haematology (Br J Haematol) Vol. 62 Issue 4 Pg. 715-22 (Apr 1986) ISSN: 0007-1048 [Print] England
• PMID: 3485993 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Colony-Stimulating Factors

Topics

• Blood Platelet Disorders (pathology, urine)
• Cell Count
• Colony-Stimulating Factors (urine)
• Humans
• Leukemia, Myeloid, Acute (drug therapy, pathology, urine)
• Megakaryocytes (pathology)
• Platelet Count