Effect of 2,5-hexanedione on lymphoid organs of rats: a preliminary report.

Abstract

Preliminary studies related to immunotoxicologic effects of 2,5-hexanedione, the final major metabolite of n-hexane/MnBk, were carried out in rats following single or repeated exposures. Female albino rats were given either single or seven consecutive oral doses of 0.1, 0.2, or 0.5 X LD50 of 2,5-hexanedione, and a time-related kinetic study was performed using hematology, histology, cellularity, and organ weight/body weight as major parameters. Following single exposure of 2,5-hexanedione to rats, a dose-dependent thymic atrophy was evident at the end of 7 days. The atrophy was reversible when the animals were given 7 days nonexposure rest. In contrast, there was no thymic atrophy when the animals were exposed for 7 consecutive days. Significant decline in the cellular populations of various lymphoid organs was also observed in rats exposed either to single or repeated doses of 2,5-hexanedione. Results obtained in the present study indicate that 2,5-hexanedione, a known potent neurotoxic substance, adversely affects the lymphoid organs of the immune system in rats.

• Authors: R K Upreti, K P Singh, A K Saxena, R Shanker
• Journal: Environmental research (Environ Res) Vol. 39 Issue 1 Pg. 188-98 (Feb 1986) ISSN: 0013-9351 [Print] Netherlands
• PMID: 3484701 (Publication Type: Journal Article)

Chemical References

• Hexanones
• Ketones
• 2,5-hexanedione

Topics

• Animals
• Cell Count (drug effects)
• Cell Survival (drug effects)
• Female
• Hexanones (toxicity)
• In Vitro Techniques
• Ketones (toxicity)
• Lethal Dose 50
• Lymph Nodes (drug effects, pathology)
• Lymphoid Tissue (drug effects, pathology)
• Organ Size (drug effects)
• Rats
• Spleen (drug effects, pathology)
• T-Lymphocytes (drug effects, pathology)
• Thymus Gland (drug effects, pathology)