Hydrocortisone valerate. Double-blind comparison with two other topical steroids.

Hydrocortisone valerate cream (0.2 percent) was evaluated in three controlled clinical trials involving a total of sixty-eight patients with atopic dermatitis. This new nonfluorinated steroid was found to be as effective as the fluorinated beta-methasone valerate cream (0.1 percent) and significantly more effective than hydrocortisone cream (0.1 percent) and the placebo cream base. All studies were double-blind, paired comparisons, utilizing application of the medications three times a day for up to four weeks or until clearing occurred.
AuthorsH L Roth, E P Brown
JournalCutis (Cutis) Vol. 21 Issue 5 Pg. 695-8 (May 1978) ISSN: 0011-4162 [Print] United States
PMID348406 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Ointments
  • Steroids, Fluorinated
  • Valerates
  • Hydrocortisone
  • Administration, Topical
  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Dermatitis, Atopic (drug therapy)
  • Double-Blind Method
  • Female
  • Humans
  • Hydrocortisone (analogs & derivatives, therapeutic use)
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Ointments
  • Steroids, Fluorinated (therapeutic use)
  • Time Factors
  • Valerates (therapeutic use)

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