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Contrasting impairments in IgM and IgG responses of vitamin A-deficient mice.

Abstract
Mice fed a semipurified, vitamin A-deficient diet (A- mice) and control animals fed the same diet with added retinyl acetate (A+ mice) were used to investigate the effect of vitamin A deficiency on primary immunoglobulin responses to protein antigens. At age 6 weeks, A- mice had serum retinol concentrations that were 46% of A+ controls. When immunized with a single antigen dose, these mice produced an antigen-specific IgM response equivalent to controls, but their IgG1 and IgG3 responses were sharply diminished (less than 30% of A+ controls). At age 8 weeks, A- mice had 20% of A+ serum retinol concentrations and less than 17% of A+ liver retinyl palmitate levels. Responding to a single antigen dose, A- mice produced approximately equal to 70% as much IgM as A+ controls. Their IgG1 response was less than 30% and their IgG3 response less than 3% of A+ controls. The IgG1 response kinetics were identical in A- and A+ mice. Diminished serum antibody responses in A- mice were attributable to fewer immunoglobulin-secreting plasma cells rather than to a decline in IgM or IgG secretion rate per cell. Total serum IgG3 levels, irrespective of antigen specificity, were slightly elevated in A- mice compared to A+ controls. The inefficient clonal expansion of responding B lymphocytes and contrasting impairment of IgM and IgG responses observed in vitamin A-deficient mice are discussed with respect to a possible helper/inducer-T-lymphocyte defect.
AuthorsS M Smith, C E Hayes
JournalProceedings of the National Academy of Sciences of the United States of America (Proc Natl Acad Sci U S A) Vol. 84 Issue 16 Pg. 5878-82 (Aug 1987) ISSN: 0027-8424 [Print] United States
PMID3475707 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Diterpenes
  • Immunoglobulin G
  • Immunoglobulin M
  • Retinyl Esters
  • Vitamin A
  • retinol acetate
  • Hemocyanins
  • Muramidase
Topics
  • Animals
  • Antibody Formation
  • Body Weight
  • Diterpenes
  • Hemocyanins (pharmacology)
  • Immunoglobulin G (biosynthesis)
  • Immunoglobulin M (biosynthesis)
  • Kinetics
  • Mice
  • Muramidase (pharmacology)
  • Retinyl Esters
  • Vitamin A (analogs & derivatives, blood, pharmacology)
  • Vitamin A Deficiency (immunology)

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