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Intramuscular vitamin E repletion in children with chronic cholestasis.

Abstract
Progressive spinocerebellar degeneration was identified in six children with chronic cholestatic liver disease and attributed to severe vitamin E deficiency. In addition to areflexia, ataxia, dysmetria, and diminished vibratory and position sense, three patients had pigmentary retinopathy. Abnormalities were present on electromyography, nerve conduction studies, and electroretinography. Because the vitamin E deficiency was not corrected by oral administration of massive doses of vitamin E, vitamin E was administered by the intramuscular route. With doses of 50 to 100 mg of vitamin E every three to seven days, over a 32-month interval (range, 15 to 44 months), vitamin E deficiency and abnormal red blood cell peroxide hemolysis were corrected. Other than discomfort and occasional edema at the site of injection, there were no side effects of parenteral vitamin E therapy. In several other studies intramuscular vitamin E therapy has produced significant neurologic improvement in patients with similar characteristics. In this study clinical progression of spinocerebellar degeneration was arrested but improvement could not be demonstrated despite adequate vitamin E replacement.
AuthorsD H Perlmutter, P Gross, H R Jones, A Fulton, R J Grand
JournalAmerican journal of diseases of children (1960) (Am J Dis Child) Vol. 141 Issue 2 Pg. 170-4 (Feb 1987) ISSN: 0002-922X [Print] United States
PMID3468801 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Vitamin E
Topics
  • Adolescent
  • Child
  • Child, Preschool
  • Cholestasis (complications)
  • Drug Administration Schedule
  • Humans
  • Injections, Intramuscular
  • Spinocerebellar Degenerations (etiology)
  • Time Factors
  • Vitamin E (administration & dosage, therapeutic use)
  • Vitamin E Deficiency (drug therapy, etiology)

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