[Serum and sputum levels of cefotetan used in respiratory tract infections].

Abstract

In 5 patients with respiratory tract infections, concentrations of cefotetan (CTT) in serum and sputum after 1 hour intravenous administration of 2 g of CTT to each patient were investigated, and following results were obtained. Serum levels of CTT The mean peak level of CTT was 232.0 +/- 16.2 micrograms/ml immediately after the 1 hour drip infusion, then declined gradually and was 48.0 +/- 8.8 micrograms/ml after 6 hours. Sputum levels of CTT Mean sputum levels of CTT were 2.15 +/- 0.19 micrograms/ml from 2 to 4 hours after the administration and 2.19 +/- 0.18 micrograms/ml from 4 to 6 hours. Clinical evaluation of CTT Clinical effects were excellent in 1 case, good in 3 cases and poor in 1 case. No side effects were observed.

• Authors: Y Matsumoto, Y Hitsuda, Y Sugimoto, J Ishikawa, T Sasaki
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 10 Pg. 2690-4 (Oct 1986) ISSN: 0368-2781 [Print] Japan
• PMID: 3468274 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephamycins
• Cefotetan

Topics

• Adult
• Biological Transport
• Bronchitis (drug therapy, metabolism)
• Cefotetan
• Cephamycins (blood, metabolism, therapeutic use)
• Female
• Humans
• Infusions, Intravenous
• Male
• Middle Aged
• Respiratory Tract Infections (drug therapy, metabolism)
• Sputum (metabolism)