Dose response in butylated hydroxyanisole induction of forestomach carcinogenesis in F344 rats.

Abstract

Groups of 50 6-week-old male F344 rats were given a powdered diet containing 0, 0.125, 0.25, 0.5, 1, or 2% butylated hydroxyanisole [(BHA) CAS: 25013-16-5] for 104 weeks. The highest dose--2% BHA--induced significant increase in the incidence of squamous cell carcinoma of the forestomach. Papillomas of the forestomach developed in 20 and 100% of the rats given diets containing 1 and 2% BHA, respectively. The incidence of epithelial hyperplasia of the forestomach increased with the increased BHA doses, to 100% incidence at the highest dose. Thus the incidences of proliferative and neoplastic lesions of the forestomach were dose dependent.

• Authors: N Ito, S Fukushima, S Tamano, M Hirose, A Hagiwara
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 77 Issue 6 Pg. 1261-5 (Dec 1986) ISSN: 0027-8874 [Print] United States
• PMID: 3467116 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Butylated Hydroxyanisole

Topics

• Animals
• Body Weight (drug effects)
• Butylated Hydroxyanisole (toxicity)
• Carcinoma, Squamous Cell (chemically induced)
• Dose-Response Relationship, Drug
• Hyperplasia
• Papilloma (chemically induced)
• Rats
• Rats, Inbred F344
• Stomach (pathology)
• Stomach Neoplasms (chemically induced)