[Fundamental and clinical studies on imipenem/cilastatin sodium in the field of obstetrics and gynecology].

Abstract

A combination of imipenem (MK-0787), a new carbapenem antibiotic, plus cilastatin sodium (MK-0791), a dehydropeptidase inhibitor (MK-0787/MK-0791 = 1:1) was studied in the field of obstetrics and gynecology and the following results were obtained. Absorption and penetration into genital organ tissues were good. Following a 0.5 g/0.5 g intravenous drip infusion, the maximum plasma concentration in uterine arterial blood was 20.8 micrograms/ml, and the maximum concentrations of the drug in tissues were 9.9 approximately 16.8 micrograms/g, and these levels of MK-0787 exceeded the MIC values against main causative organisms. Rates of elimination of the drug from the tissue and from the plasma were similar. Against gynecological and obstetrical infections, a dose of 0.5 g/0.5 g twice daily for an average duration of 6.3 days produced a clinical efficacy ratio of 94.4% (17/18) and a bacteriological effects rating of 76.9% (10/13). As side effects, one patient showed an eruption and another had an elevated GOT and GPT. Based on the above results, MK-0787/MK-0791 appears to be effective against gynecological and obstetrical infections.

• Authors: N Cho, K Fukunaga, K Kunii
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 39 Issue 5 Pg. 1359-71 (May 1986) ISSN: 0368-2781 [Print] Japan
• PMID: 3463782 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclopropanes
• Drug Combinations
• Thienamycins
• Cilastatin
• Imipenem

Topics

• Adult
• Aged
• Bacterial Infections (drug therapy)
• Cilastatin
• Cyclopropanes (administration & dosage, metabolism)
• Drug Combinations
• Female
• Genital Diseases, Female (drug therapy)
• Genitalia, Female (metabolism)
• Humans
• Imipenem
• Kinetics
• Middle Aged
• Postoperative Complications (drug therapy)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy)
• Thienamycins (administration & dosage, metabolism)