Translocation (9;11)(p21;q23) in a child with acute monoblastic leukemia following 2 1/2 years after successful chemotherapy for neuroblastoma.

Abstract

This is a case report of a 4 1/2-year-old boy who developed acute monoblastic leukemia 2 1/2 years after he had been treated successfully with combined chemotherapy for neuroblastoma. All analyzable bone marrow-derived metaphases had the karyotype 47,XY, + 8,t(9;11)(p21;q23). The rare occurrence of specific chromosomal translocations in leukemias following prior chemotherapy and/or radiotherapy and their possible clinical implications in such cases are discussed.

• Authors: H J Weh, H Kabisch, G Landbeck, D K Hossfeld
• Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (J Clin Oncol) Vol. 4 Issue 10 Pg. 1518-20 (Oct 1986) ISSN: 0732-183X [Print] United States
• PMID: 3463672 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Acute Disease
• Adrenal Gland Neoplasms (drug therapy, pathology)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Bone Marrow (ultrastructure)
• Child, Preschool
• Humans
• Karyotyping
• Leukemia, Monocytic, Acute (chemically induced, genetics)
• Male
• Neuroblastoma (drug therapy, pathology)
• Translocation, Genetic