Pefloxacin concentrations in human aqueous humour and lens.

In 20 patients undergoing cataract extraction, we measured pefloxacin concentrations in the eye. After a 1 h infusion of pefloxacin 400 mg iv, the mean pefloxacin concentrations 2, 6, 12 and 24 h post-infusion were 0.75, 1.45, 1.04 and 0.86 mg/l, respectively. The simultaneous mean pefloxacin concentrations in the lens were 0.09, 0.20, 0.26 and 0.43 mg/l, respectively. The adequate penetration of pefloxacin into uninfected aqueous humour and lens suggests that this antibiotic may be effective in the treatment of certain bacterial endophthalmic infections.
AuthorsA Salvanet, A Fisch, C Lafaix, G Montay, P Dubayle, F Forestier, G Haroche
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 18 Issue 2 Pg. 199-201 (Aug 1986) ISSN: 0305-7453 [Print] ENGLAND
PMID3463558 (Publication Type: Journal Article)
Chemical References
  • Pefloxacin
  • Norfloxacin
  • Aged
  • Aged, 80 and over
  • Aqueous Humor (metabolism)
  • Female
  • Humans
  • Infusions, Intravenous
  • Lens, Crystalline (metabolism)
  • Male
  • Middle Aged
  • Norfloxacin (analogs & derivatives, blood, metabolism)
  • Pefloxacin

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