Abstract |
In 20 patients undergoing cataract extraction, we measured pefloxacin concentrations in the eye. After a 1 h infusion of pefloxacin 400 mg iv, the mean pefloxacin concentrations 2, 6, 12 and 24 h post-infusion were 0.75, 1.45, 1.04 and 0.86 mg/l, respectively. The simultaneous mean pefloxacin concentrations in the lens were 0.09, 0.20, 0.26 and 0.43 mg/l, respectively. The adequate penetration of pefloxacin into uninfected aqueous humour and lens suggests that this antibiotic may be effective in the treatment of certain bacterial endophthalmic infections.
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Authors | A Salvanet, A Fisch, C Lafaix, G Montay, P Dubayle, F Forestier, G Haroche |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 18
Issue 2
Pg. 199-201
(Aug 1986)
ISSN: 0305-7453 [Print] England |
PMID | 3463558
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Aqueous Humor
(metabolism)
- Female
- Humans
- Infusions, Intravenous
- Lens, Crystalline
(metabolism)
- Male
- Middle Aged
- Norfloxacin
(analogs & derivatives, blood, metabolism)
- Pefloxacin
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