Prednisone stimulation of erythropoiesis in leukemic children during remission.

Abstract

Children with acute leukemia in remission manifest reticulocytosis and a significant increase in hemoglobin concentration (mean increment of 2.3 +/- 1.1 g/dl) following prednisone pulse therapy. This hemoglobin increment is not associated with changes in serum erythropoietin activity. It is speculated that this stimulation of red cell production may be a direct effect of steroids on erythroid progenitor cells.

• Authors: M D Amylon, S P Perrine, B E Glader
• Journal: American journal of hematology (Am J Hematol) Vol. 23 Issue 2 Pg. 179-81 (Oct 1986) ISSN: 0361-8609 [Print] United States
• PMID: 3463202 (Publication Type: Journal Article)

Chemical References

• Hemoglobins
• Prednisone

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Child
• Erythropoiesis (drug effects)
• Hemoglobins (analysis)
• Humans
• Leukemia, Lymphoid (blood, drug therapy)
• Prednisone (therapeutic use)
• Reticulocytes (cytology)