Acute myelomonocytic leukemia in a horse.

Abstract

A 7-year-old Quarter Horse stallion with a myeloproliferative disorder was examined because of colic, and an enterolith was removed surgically. The horse experienced secondary complications after abdominal surgery, and leukopenia and thrombocytopenia were detected. Five months later, the horse was examined for recurrent peripheral edema and for repair of an abdominal incisional hernia. Acute myelomonocytic leukemia was diagnosed, and treatment with low-dose (noncytocidal) cytosine arabinoside was unsuccessful. Necropsy revealed neoplastic infiltrate in the spleen, liver, lung, adrenal gland, testes, and eye. The persistent hematologic abnormalities before the onset of overt leukemia may represent hematopoietic dysplasia or preleukemia.

• Authors: S J Spier, B R Madewell, J G Zinkl, A M Ryan
• Journal: Journal of the American Veterinary Medical Association (J Am Vet Med Assoc) Vol. 188 Issue 8 Pg. 861-3 (Apr 15 1986) ISSN: 0003-1488 [Print] United States
• PMID: 3458690 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Horse Diseases (diagnosis, pathology)
• Horses
• Leukemia, Myeloid (diagnosis, pathology, veterinary)
• Male