Isothiazolopyrimidines--new group of anticancer agents. II.

Abstract	In reactions of 5-aminoisothiazolopyrimidines 1 with glycosilisothiocyanates and phenyl isocyano- or isocyanates, N-glycosilo-N-phenylo- and N-isothiazolopyrimidinothiocarbamides type II were obtained. The same compound--5-aminoisothiazolopyrimidine 1 in reaction with glucose, arabinose and ribose bromoderivatives was converted into N-glycosiloaminoisothiazolopyrimidies type 3. Some of the newly synthetized compounds appeared effective against L-1210 leukemia and Sa-180 sarcoma.
Authors	Z Machoń, I Mielczarek, J Wieczorek, M Mordarski
Journal	Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 35 Issue 5 Pg. 609-16 ( 1987) ISSN: 0004-069X [Print] Switzerland
PMID	3455650 (Publication Type: Journal Article)
Chemical References	Antineoplastic Agents Pyrimidines Thiazoles
Topics	Animals Antineoplastic Agents (chemical synthesis, therapeutic use) Cell Division (drug effects) Chemical Phenomena Chemistry Drug Screening Assays, Antitumor Leukemia L1210 (drug therapy, mortality, pathology) Mice Pyrimidines (chemical synthesis, therapeutic use) Sarcoma, Experimental (drug therapy, mortality, pathology) Thiazoles (chemical synthesis, therapeutic use)

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