Abstract |
The effect of preexisting pulmonary disease on the deposition and retention of inhaled relatively insoluble radiolabeled particles was studied. Two dogs were exposed to 500 ppm sulfur dioxide 2 h/day, 5 days/week for 16 weeks and two dogs were sham-exposed to filtered air for the same period. Dogs exposed to sulfur dioxide developed chronic bronchitis during this exposure period. After the bronchitis had been established for 10 weeks, all 4 dogs were exposed by inhalation to 1.7 micron aerodynamic diameter 134Cs-labeled fused aluminosilicate particles (FAP) and the exposures to SO2 were discontinued. The bronchitis resolved within 4 weeks after SO2 was discontinued. Dogs were periodically whole-body counted and excreta were periodically collected and counted over a 385-day period following the 134Cs exposure. Deposition of the [134Cs]FAP in the pulmonary region averaged 42% for control dogs and 16% for dogs exposed to SO2; deposition in extrapulmonary regions of the respiratory tract averaged 58% for control dogs and 84% for dogs exposed to SO2. Although deposition patterns were different, early and long-term clearance pathways and rates were the same for all dogs, as indicated by analysis of whole body, excreta, and tissues for their burdens of 134Cs.
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Authors | S A Greene, D L Lundgren, M B Snipes, R K Wolff |
Journal | Experimental lung research
(Exp Lung Res)
Vol. 13
Issue 4
Pg. 417-25
( 1987)
ISSN: 0190-2148 [Print] England |
PMID | 3447886
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Aerosols
- Aluminum Silicates
- Sulfur Dioxide
- aluminosilicate
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Topics |
- Aerosols
- Aluminum Silicates
(administration & dosage, metabolism, pharmacokinetics)
- Animals
- Bronchitis
(chemically induced, metabolism)
- Chronic Disease
- Dogs
- Lung
(metabolism)
- Sulfur Dioxide
- Tissue Distribution
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