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Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.

Abstract
Twenty male combinative cocaine free-base/phencyclidine (space-base) abusers were studied for forty-five days, in a double-blind design. Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms. This study tends to support the catecholamine-depletion hypothesis of cocaine and phencyclidine withdrawal.
AuthorsA J Giannini, R H Loiselle, M C Giannini
JournalJournal of toxicology. Clinical toxicology (J Toxicol Clin Toxicol) Vol. 25 Issue 6 Pg. 493-500 ( 1987) ISSN: 0731-3810 [Print] UNITED STATES
PMID3441016 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Cocaine
  • Phencyclidine
  • Desipramine
Topics
  • Adult
  • Cocaine (adverse effects)
  • Desipramine (therapeutic use)
  • Double-Blind Method
  • Humans
  • Male
  • Phencyclidine (adverse effects)
  • Psychotherapy, Brief
  • Substance Withdrawal Syndrome (drug therapy)

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