[Immunomorphologic study of the early stages of amyloidogenesis].

Abstract

Early stages of amyloidogenesis were studied in mice with experimental amyloidosis. According to indirect Coons' method the cryostat sections of the spleens and other organs of mice were incubated first with pure rabbit fibrillar protein antiamyloid antibodies, and then with pure fluorescein-labeled foat antirabbit IgG antibodies. At the early period after 1--2 casein injections there appeared amyloid protein in the intercellular space and in the blood filling the spleen and liver sinuses. Formation of the typical amyloid deposits in the spleen were completed by the 5th--7th day of the experiment after 3--4 casein injections.

• Authors: L N Kapinus
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 85 Issue 2 Pg. 232-4 (Feb 1978) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Immunomorfologicheskoe izuchenie rannikh stadiĭ amiloidogeneza.
• PMID: 343835 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amyloid

Topics

• Amyloid (biosynthesis)
• Amyloidosis (metabolism)
• Animals
• Fluorescent Antibody Technique
• Kidney (metabolism)
• Mice
• Spleen (metabolism)