Cataract formation in diabetic patients and galactose-1-phosphate uridyltransferase deficiency.

Abstract

We have evaluated the levels of red blood cell galactose-1-phosphate uridyltransferase in 20 patients with cataract and in 15 subjects without cataract, suffering from compensated, noninsulin-dependent, type II diabetes. The diabetic patients were compared with a previously examined group of 65 age-matched nondiabetic subjects (25 of whom suffered from bilateral idiopathic cataract). In diabetic patients, the average galactose-1-phosphate uridyltransferase levels tended to be lower and the percentage of cases of reduced enzymatic activity tended to be higher than in the corresponding nondiabetic subjects.

• Authors: F Simonelli, S Savastano, E Rinaldi, G Auricchio
• Journal: Ophthalmic research (Ophthalmic Res) Vol. 19 Issue 5 Pg. 261-5 ( 1987) ISSN: 0030-3747 [Print] Switzerland
• PMID: 3438044 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Aged
• Animals
• Cataract (etiology, pathology)
• Diabetes Mellitus, Type 2 (blood, complications, enzymology, therapy)
• Drinking
• Erythrocytes (enzymology)
• Female
• Humans
• Male
• Middle Aged
• Milk
• Oxidation-Reduction