[Treatment of infantile hydrocephalus with isosorbide dinitrate (author's transl)].

Abstract

Eighteen of infantile hydrocephalus have been treated with isosorbide dinitrate. Pharmacology of this compound is considered. It appears that completely dinitrated isosorbide is the major metabolite. Isosorbide may be effective in a variable proportion of various types of infantile hydrocephalus. Results of isosorbide dinitrate therapy in children with "communicating" and "noncommunicating" hydrocephalus are reported. Treatment was monitored by simple measurements, and it's toxicity proved to be scanty.

• Authors: M Nieto Barrera, R Candáu Fernández-Mensaque, M Rufo Campos, G Rodríguez Criado, B Barrionuevo Gallo
• Journal: Anales espanoles de pediatria (An Esp Pediatr) Vol. 10 Issue 11 Pg. 843-56 (Nov 1977) ISSN: 0302-4342 [Print] Spain
• Vernacular Title: El tratamiento de la hidrocefalia infantil con dinitrato de isosorbide.
• PMID: 343675 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Isosorbide Dinitrate

Topics

• Administration, Oral
• Cerebral Ventriculography
• Child
• Clinical Trials as Topic
• Drug Evaluation
• Female
• Humans
• Hydrocephalus (diagnostic imaging, drug therapy)
• Isosorbide Dinitrate (therapeutic use)
• Male