Efficacy of sulbactam-ampicillin in an induced Pasteurella haemolytica pneumonia model in calves.

Abstract

Therapeutic efficacy of sulbactam, a beta-lactamase inhibitor, in combination with ampicillin was evaluated in an ampicillin-resistant Pasteurella haemolytica pneumonia model in cattle, using an IV agar emboli method of infection. Groups of cattle given vehicle (group 1, n = 19) or ampicillin (group 2, n = 8) had 74% and 50% mortality, respectively, whereas group 3 (n = 11) given sulbactam-ampicillin had no mortality. Morbidities were 100% in groups 1 and 2 and 27% in group 3. Retrospectively, mortalities and morbidities were significantly (P less than 0.001) lower for group 3 given sulbactam-ampicillin when compared with those in groups 1 and 2 given vehicle or ampicillin, respectively. Evidence of embolic pneumonic pasteurellosis was observed histologically.

• Authors: D O Farrington, J A Jackson, O E Bentley, H J Barnes
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 48 Issue 12 Pg. 1684-8 (Dec 1987) ISSN: 0002-9645 [Print] United States
• PMID: 3434913 (Publication Type: Journal Article)

Chemical References

• Drug Combinations
• Ampicillin
• Sulbactam

Topics

• Ampicillin (administration & dosage)
• Ampicillin Resistance
• Animals
• Cattle
• Cattle Diseases (drug therapy)
• Drug Combinations
• Drug Resistance, Microbial
• Drug Synergism
• Injections, Intramuscular
• Pasteurella Infections (drug therapy, veterinary)
• Pneumonia (drug therapy, veterinary)
• Sulbactam (administration & dosage)