[Protective action of remantadine in experimental influenzal-staphylococcal infection].

Abstract

The effect of remantadine on the course of influenzal-staphylococcal infection was studied in white mice. When the drug was injected to the mice infected with remantadine-sensitive strain of influenza A virus and Staphylococcus the lethality decreased from 93.3% to 26.7%, the survival time increased from 3.8 to 10.1 days, the incidence of pneumonia decreased from 85.7% to 48.7%, the average intensity of pneumonia decreased from 66.4% to 9.9%, and virus titres in the lungs decreased by 3.5-4.0 lg EID50 (p less than 0.05). In the groups of mice infected with remantadine-resistant strain of influenza virus and Staphylococcus remantadine showed no significant effect on these parameters: the lethality decreased by 6.7% only, the average survival time increased only by 0.33 days, the incidence of pneumonia decreased by 9%, its intensity by 19.2%; influenza virus titres in the lung tissue did not change significantly.

• Authors: M L Medvedev, A M Koroliuk
• Journal: Voprosy virusologii (Vopr Virusol) 1987 Sep-Oct Vol. 32 Issue 5 Pg. 538-40 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Zashchitnoe deĭstvie remantadina pri éksperimental'noĭ grippozno-stafilokokkovoĭ infektsii.
• PMID: 3433711 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Rimantadine
• Adamantane

Topics

• Adamantane (analogs & derivatives)
• Animals
• Drug Evaluation, Preclinical
• Drug Resistance, Microbial
• Influenza A virus (drug effects, physiology)
• Mice
• Orthomyxoviridae Infections (drug therapy, mortality)
• Rimantadine (therapeutic use)
• Staphylococcal Infections (drug therapy, mortality)
• Time Factors
• Virus Replication (drug effects)