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Short-term intensive cyclophosphamide treatment in progressive multiple sclerosis.

Abstract
14 patients with chronic progressive multiple sclerosis, selected in a preliminary uncontrolled trial, were given a short course of intensive cyclophosphamide therapy, which was discontinued when the leukocyte count fell to 3000 cu.mm. 5 patients dropped out because of severe side effects. At 1 year follow-up were neurologically unchanged since admission to the trial; 4 remained stable at 2 years. The lack of clinical improvement, the high frequency of side effects and the proven oncogenicity of cyclophosphamide led us to discontinue the trial.
AuthorsG F Siracusa, M P Amato, L Fratiglioni, D Sità, L Amaducci
JournalItalian journal of neurological sciences (Ital J Neurol Sci) Vol. 8 Issue 6 Pg. 589-92 (Dec 1987) ISSN: 0392-0461 [Print] Italy
PMID3429217 (Publication Type: Journal Article)
Chemical References
  • Cyclophosphamide
Topics
  • Adult
  • Cyclophosphamide (adverse effects, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis (drug therapy)

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