Abstract |
14 patients with chronic progressive multiple sclerosis, selected in a preliminary uncontrolled trial, were given a short course of intensive cyclophosphamide therapy, which was discontinued when the leukocyte count fell to 3000 cu.mm. 5 patients dropped out because of severe side effects. At 1 year follow-up were neurologically unchanged since admission to the trial; 4 remained stable at 2 years. The lack of clinical improvement, the high frequency of side effects and the proven oncogenicity of cyclophosphamide led us to discontinue the trial.
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Authors | G F Siracusa, M P Amato, L Fratiglioni, D Sità, L Amaducci |
Journal | Italian journal of neurological sciences
(Ital J Neurol Sci)
Vol. 8
Issue 6
Pg. 589-92
(Dec 1987)
ISSN: 0392-0461 [Print] Italy |
PMID | 3429217
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Cyclophosphamide
(adverse effects, therapeutic use)
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Multiple Sclerosis
(drug therapy)
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