Pharmacokinetic studies with zinc(II)-phthalocyanine in tumour-bearing mice.

Abstract

Zn(II)-phthalocyanine (Zn-Pc) incorporated into unilamellar liposomes of dipalmitoylphosphatidylcholine has been injected intraperitoneally (0.5 mg kg-1) to BALB/c mice bearing a transplanted MS-2 fibrosarcoma. The drug is specifically transported by serum lipoproteins and cleared from the serum via the bile-gut pathway in a biphasic process: approximately 60% of Zn-Pc is eliminated with a serum half-life of approximately 9 hours, while the remaining aliquot is eliminated at a very slow rate. Several normal tissues take up the drug within 3 hours after administration but release it almost completely after 24-48 hours. On the other hand, the tumour shows a maximum concentration of Zn-Pc (approximately 0.6 microgram g-1 of tissue) after 18-24 hours; at this time, the ratio between the Zn-Pc levels in the tumour and the muscle (which represents the surrounding normal tissue) is approximately 7.5. The results are discussed in terms of a possible use of Zn-Pc as a photosensitizer in the photodynamic therapy of tumours.

• Authors: E Reddi, G Lo Castro, R Biolo, G Jori
• Journal: British journal of cancer (Br J Cancer) Vol. 56 Issue 5 Pg. 597-600 (Nov 1987) ISSN: 0007-0920 [Print] England
• PMID: 3426922 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Indoles
• Isoindoles
• Lipoproteins
• Liposomes
• Organometallic Compounds
• Pigments, Biological
• Zinc Compounds
• Zn(II)-phthalocyanine
• Zinc

Topics

• Animals
• Female
• Fibrosarcoma (blood, metabolism)
• Half-Life
• Indoles (blood, pharmacokinetics)
• Isoindoles
• Lipoproteins (blood)
• Liposomes
• Mice
• Mice, Inbred BALB C
• Muscles (metabolism)
• Organometallic Compounds (blood, pharmacokinetics)
• Pigments, Biological (blood, pharmacokinetics)
• Rats
• Time Factors
• Tissue Distribution
• Zinc (blood, pharmacokinetics)
• Zinc Compounds