[Antiemetic efficacy of high-dose metoclopramide, diphenhydramine, methylprednisolone and diazepam on chemotherapy-induced emesis in gynecological malignancy].

Abstract

The antiemetic efficacy of high-dose metoclopramide (MCP), diphenhydramine (DPH), methylprednisolone (MPL), and diazepam (DZP) was investigated in 40 gynecologic cancer patients for a total of 98 chemotherapy courses, treated with cisplatin (50 mg/m2). With MPL (500 mg i.v. x 2) plus DZP (5 mg i.m. x 2), no vomiting occurred in 0% and mild emesis (vomiting 1-2 times) occurred in 20% of 25 courses. With MCP (2 mg/kg i.v. x 5) plus DPH (40 mg i.v. x 3), no vomiting occurred in 35% and mild emesis occurred in 10% of 20 courses. With a combination of MCP plus DPH and MPL plus DZP, no vomiting occurred in 51% and mild emesis occurred in 25% of 53 courses. These results indicate that high-dose MCP plus DPH are effective in preventing cisplatin-induced vomiting. Furthermore, the antiemetic efficacy of MCP plus DPH (0-2 vomiting episodes: 45%) was significantly enhanced (p less than 0.05) by the combined use of MPL plus DZP (0-2 vomiting episodes: 76%).

• Authors: Y Hayashi, T Iwasaka, T Hachisuga, K Fukuda, T Tanaka, N Matsuo, H Sugimori
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 40 Issue 7 Pg. 875-9 (Jul 1988) ISSN: 0300-9165 [Print] Japan
• PMID: 3418195 (Publication Type: English Abstract, Journal Article)

Chemical References

• Diphenhydramine
• Metoclopramide
• Cisplatin
• Diazepam
• Methylprednisolone

Topics

• Adult
• Aged
• Cisplatin (adverse effects)
• Diazepam (administration & dosage)
• Diphenhydramine (administration & dosage)
• Drug Therapy, Combination
• Female
• Genital Neoplasms, Female (drug therapy)
• Humans
• Methylprednisolone (administration & dosage)
• Metoclopramide (administration & dosage)
• Middle Aged
• Vomiting (chemically induced, drug therapy)