Clearance of bromosulphthalein from plasma as a measure of hepatic function in normal horses and in horses with liver disease.

Abstract

Single intravenous injections of bromosulphthalein (BSP) were given to horses and the change in plasma concentration of BSP with time was analysed by computer to obtain the proportionality transfer constants 'a', 'h' and 'b'. No age, weight or sex differences in BSP clearance were found in normal horses. The technique was non-invasive, repeatable and suitable for conscious animals. The measurement of the transfer constants 'a', 'h' and 'b', helped to provide an accurate guide to diagnosis and prognosis of liver disease.

• Authors: H J West
• Journal: Research in veterinary science (Res Vet Sci) Vol. 44 Issue 3 Pg. 343-8 (May 1988) ISSN: 0034-5288 [Print] England
• PMID: 3406531 (Publication Type: Journal Article)

Chemical References

• Sulfobromophthalein

Topics

• Animals
• Female
• Horse Diseases (blood, metabolism, physiopathology)
• Horses (physiology)
• Liver Diseases (blood, metabolism, physiopathology, veterinary)
• Liver Function Tests (veterinary)
• Male
• Sulfobromophthalein (blood, pharmacokinetics)