In this study, four patients presented with
chronic urticaria that required glucocorticosteroid
therapy for control. In the first patient, the
urticaria began during pregnancy and persisted after delivery with symptoms flaring premenstrually thereafter.
Danazol was selected in an attempt to suppress
progesterone levels, theoretically by inhibiting ovulation. The patient's
urticaria markedly improved, however, within 24 hours. Several months later, she was switched to
stanozolol with further improvement. Three other individuals were treated with
stanozolol with dramatic improvement. In all, three patients have experienced the induction of five remissions (there were two recurrences), and one patient remains much improved. All subjects have stopped both
stanozolol and glucocorticosteroids.
Stanozolol appears to act synergistically with glucocorticosteroids, and together, they may be capable of inducing remission in some patients.