Abstract |
Previous studies have shown that cefoperazone given in frequent, large doses is effective in the treatment of infection in patients with cancer. The pharmacodynamics of 2- and 4-g doses of cefoperazone administered either as a single dose or at 12-hour intervals were studied in an in vitro model that simulates infection in a neutropenic patient. One strain each of Pseudomonas aeruginosa (minimal inhibitory concentration [MIC] = 2 micrograms/ml), Staphylococcus aureus (MIC = 1 microgram/ml), Escherichia coli (MIC = 0.06 micrograms/ml), and Klebsiella pneumoniae (MIC = 0.25 micrograms/ml) was studied. The initial dose reduced the inoculum by approximately 3 logs for the Pseudomonas and the staphylococci and 3 to 5 logs for the other organisms. No significant differences in killing were found between the 2- and 4-g doses. Regrowth of Pseudomonas and staphylococci occurred with the single dose but not with the every-12-hour regimen. These data support the clinical use of cefoperazone in doses every 12 hours.
|
Authors | S H Zinner, M N Dudley, D Gilbert, M Bassignani |
Journal | The American journal of medicine
(Am J Med)
Vol. 85
Issue 1A
Pg. 56-8
(Jul 25 1988)
ISSN: 0002-9343 [Print] United States |
PMID | 3400681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Agranulocytosis
(complications)
- Bacteria
(drug effects)
- Bacterial Infections
(complications, microbiology)
- Cefoperazone
(administration & dosage, pharmacology)
- Drug Administration Schedule
- Kinetics
- Models, Biological
- Neutropenia
(complications)
|