Genetic studies of human apolipoproteins. III. Polymorphism of apolipoprotein C-II.

Abstract

Using a simple and rapid one-dimensional isoelectric focusing technique followed by immunoblotting, we have detected genetic polymorphism of human apolipoprotein C-II (APO C-II) in normal unfractionated plasma samples of individuals of black ancestry. Two common autosomal codominantly expressed alleles, designated APO C-II*1 and APO C-II*2, at the APO C-II structural locus have been observed with frequencies of 0.975 and 0.025 in US blacks and 0.943 and 0.049 in Nigerian blacks. In addition, the gene product of a rare allele designated APO C-II*3 was observed in a single Nigerian black. Apart from a single example of an APO C-II 2-1 phenotype in plasma samples from 187 whites, which was electrophoretically identical to the 2-1 phenotype observed in blacks, it appears that APO C-II*2 is a unique black marker of potential importance in anthropogenetic and atherosclerosis studies.

• Authors: B Sepehrnia, M I Kamboh, R E Ferrell
• Journal: Human heredity (Hum Hered) Vol. 38 Issue 3 Pg. 136-43 ( 1988) ISSN: 0001-5652 [Print] Switzerland
• PMID: 3397066 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Apolipoprotein C-II
• Apolipoproteins C

Topics

• Alleles
• Apolipoprotein C-II
• Apolipoproteins C (blood, genetics)
• Black People
• Electrophoresis, Polyacrylamide Gel
• Humans
• Immunochemistry
• Isoelectric Focusing
• Nigeria
• Phenotype
• Polymorphism, Genetic