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[Serum, synovial and intra-articular pharmacokinetics of naproxen after one-gram oral administration in patients with rheumatoid polyarthritis].

Abstract
After a reminder of the major points of the pharmacokinetics of non-steroid anti-inflammatory drugs, the authors report the results of a multicentric study of the kinetics of naproxen after oral intake of one single dose of 1 gram in patients with rheumatoid arthritis. The half-life is longer in the synovial fluid than in the serum, 23 hours versus 17 hours. The balance point is obtained at the 24th hour and, at that time, the naproxen level in the synovium and the joint fluid are 32 and 60 p. cent, respectively, of the corresponding maximum concentrations.
AuthorsJ C Renier, C Masson, F Baudel, M Bouvier, B Delcambre, B Fournié, A Heraud, B Hercelin, L Jube, C Menkes
JournalRevue du rhumatisme et des maladies osteo-articulaires (Rev Rhum Mal Osteoartic) Vol. 55 Issue 6 Pg. 435-9 (Apr 30 1988) ISSN: 0035-2659 [Print] France
Vernacular TitlePharmacocinétique plasmatique, synoviale et intra-articulaire du naproxène après administration orale d'un gramme chez des sujets atteints de polyarthrite rhumatoïde.
PMID3393838 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Naproxen
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Arthritis, Rheumatoid (drug therapy, metabolism)
  • Humans
  • Joints (metabolism)
  • Middle Aged
  • Naproxen (administration & dosage, blood, pharmacokinetics)
  • Synovial Fluid (metabolism)

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