Suppression of lymphocyte function with breast carcinoma I-active glycopeptides.

Abstract

Patients with metastatic breast carcinoma (BCa) have defective peripheral blood lymphocyte (PBL) responsiveness to mitogenic and antigenic stimulation. In the following experiments, glycopeptides were isolated from the pronase digests of breast carcinoma tissue. After elution from Sephadex G-50, glycopeptides from BCa inhibited PBL responsiveness to mitogenic (PHA) stimulation. The glycopeptides contained blood group I-antigenic determinants. These experiments demonstrate the presence of blood group I-active peptides in breast carcinoma that suppress peripheral blood lymphocyte functions. Further studies are in progress.

• Authors: V E Dube, P Kallio, A Hakim
• Journal: Immunological investigations (Immunol Invest) Vol. 17 Issue 1 Pg. 19-24 (Mar 1988) ISSN: 0882-0139 [Print] England
• PMID: 3391650 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Group Antigens
• Glycopeptides
• I Blood-Group System
• Immunosuppressive Agents

Topics

• Blood Group Antigens (immunology)
• Breast Neoplasms (immunology)
• Glycopeptides (physiology)
• Humans
• I Blood-Group System (immunology)
• Immune Tolerance
• Immunosuppressive Agents (isolation & purification)
• In Vitro Techniques
• Lymphocyte Activation
• Lymphocytes (immunology)