Abstract |
SK-UT-1B (ATCC HTB 115) produced tumors 2 weeks after subcutaneous injection of 10 million cells into athymic nude mice. Karyotypic analysis at the 500-600 subband level, however, did not reveal any noticeable aberrations. This cell line therefore may represent the first example of experimentally proven human tumorigenic cells of solid tumor origin that retains the diploid karyotype in vitro indefinitely.
|
Authors | T R Chen |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 33
Issue 1
Pg. 77-81
(Jul 01 1988)
ISSN: 0165-4608 [Print] United States |
PMID | 3383166
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
|
Topics |
- Aged
- Animals
- Diploidy
- Female
- Humans
- Karyotyping
- Leiomyosarcoma
(genetics, pathology)
- Mice
- Mice, Nude
- Neoplasm Transplantation
- Tumor Cells, Cultured
(pathology)
- Uterine Neoplasms
(genetics, pathology)
|