Transfer of enprofylline into breast milk.

Abstract

Enprofylline concentrations were measured on 3 consecutive days in milk and plasma from six nursing mothers who were treated twice daily with 150-mg enprofylline slow-release tablets. The mean plasma concentration was 0.89 mg/L and the mean milk concentration was 0.71 mg/L, the average milk/plasma ratio being 0.80. The mean milk/plasma ratio ranged from 0.67 to 0.98 in the six mothers. It was estimated that a maximum of approximately 10% of an adult dose of enprofylline, on a per-kilogram body-weight basis, may be transferred to the suckling infant.

• Authors: L C Laursen, O Borgå, K Ljungholm, B Weeke
• Journal: Therapeutic drug monitoring (Ther Drug Monit) Vol. 10 Issue 2 Pg. 150-2 ( 1988) ISSN: 0163-4356 [Print] United States
• PMID: 3381231 (Publication Type: Journal Article)

Chemical References

• Bronchodilator Agents
• Delayed-Action Preparations
• Xanthines
• enprofylline

Topics

• Adult
• Bronchodilator Agents (administration & dosage, blood, pharmacokinetics)
• Delayed-Action Preparations
• Female
• Half-Life
• Humans
• Milk, Human (metabolism)
• Xanthines (administration & dosage, blood, pharmacokinetics)