Malignant acanthosis nigricans associated with non-Hodgkin's lymphoma. Report of 2 cases.

Abstract

Two cases of malignant acanthosis nigricans associated with non-Hodgkin's lymphoma are presented. A 61-year-old negro male with a diffuse large cell non-Hodgkin's lymphoma presented extensive acanthosis nigricans, pachydermatoglyphy and florid cutaneous papillomatosis. No viral particles were observed by electron microscopic studies of the wart-like lesions. Acanthosis nigricans disappeared under chemotherapy. The second case was a 21-year-old caucasian male with non T non B diffuse large cell non-Hodgkin's lymphoma. Very few cases of acanthosis nigricans associated with non-Hodgkin's lymphoma have been reported in the literature, since to our knowledge these two are only the fourth and fifth. Pachydermatoglyphy and florid cutaneous papillomatosis are markers of malignant acanthosis nigricans.

• Authors: M Janier, C Blanchet-Bardon, D Bonvalet, M Lenoble, F Boiget, J Civatte
• Journal: Dermatologica (Dermatologica) Vol. 176 Issue 3 Pg. 133-7 ( 1988) ISSN: 0011-9075 [Print] Switzerland
• PMID: 3378650 (Publication Type: Case Reports, Journal Article)

Topics

• Acanthosis Nigricans (complications, pathology)
• Adult
• Dermatoglyphics
• Humans
• Lymphoma, Non-Hodgkin (complications, pathology)
• Male
• Middle Aged
• Neoplasms, Multiple Primary (pathology)
• Papilloma (complications, pathology)
• Skin Neoplasms (complications, pathology)