Catecholamine and blood pressure levels in paralysed preterm ventilated infants.

Abstract

The effect of pancuronium administration on catecholamine levels and blood pressure was investigated. Noradrenaline levels prior to paralysis amongst infants fighting the ventilator were high, but were significantly reduced following treatment with pancuronium. There was no significant change in either blood pressure or adrenaline levels. Increasing peak inspiratory pressure (approx. 4 cmH2O) immediately prior to paralysis effectively prevented the hypoventilation previously associated with the administration of the first dose of pancuronium.

• Authors: A Greenough, J Pool, H Lagercrantz
• Journal: Early human development (Early Hum Dev) Vol. 16 Issue 2-3 Pg. 219-24 (Mar 1988) ISSN: 0378-3782 [Print] Ireland
• PMID: 3378527 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Catecholamines
• Pancuronium
• Norepinephrine
• Epinephrine

Topics

• Blood Pressure (drug effects)
• Catecholamines (blood)
• Epinephrine (blood)
• Female
• Humans
• Infant, Newborn
• Infant, Premature
• Male
• Norepinephrine (blood)
• Pancuronium (adverse effects)
• Paralysis
• Respiration, Artificial