Efficacy of various anthelmintics against third-stage larvae of Ancylostoma caninum in the brain of mice.

Abstract

In an experimental larval infection of Ancylostoma caninum in mice, the efficacy of various anthelmintics against the larvae migrated and established in the brain is reported for the first time. Albendazole and flubendazole were the most effective drugs. Thiabendazole, benacil, phenacizole, oxfendazole and mebendazole showed significant larvicidal activity. Tetramisole, levamisole, fenbendazole, Sch 18099, pyrantel pamoate, morantel tartrate and oxantel pamoate did not show any significant activity even at relatively high dose levels.

• Authors: G M Bhopale, B S Bhatnagar
• Journal: Journal of helminthology (J Helminthol) Vol. 62 Issue 1 Pg. 40-4 (Mar 1988) ISSN: 0022-149X [Print] England
• PMID: 3372978 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anthelmintics

Topics

• Ancylostoma (drug effects)
• Ancylostomiasis (drug therapy, parasitology)
• Animals
• Anthelmintics (therapeutic use)
• Brain (parasitology)
• Brain Diseases (drug therapy, parasitology)
• Larva (drug effects)
• Mice