Clindamycin for colonization and infection by methicillin-resistant Staphylococcus aureus.

Abstract

Effective antimicrobial therapy for infection or colonization by methicillin-resistant Staphylococcus aureus (MRSA) is very limited. In some institutions, the majority of strains remain susceptible to clindamycin in vitro. We report five patients with colonization or infection of varying severity caused by MRSA who had the organism successfully eradicated by clindamycin. In one patient who had an MRSA infection that persisted during vancomycin therapy clindamycin therapy was able to finally eradicate the organism. Clindamycin should be seriously considered as alternative therapy for colonization or infection by MRSA.

• Authors: S M Smith, A Mangia, R H Eng, P Ruggeri, A Cytryn, F Tecson-Tumang
• Journal: Infection (Infection) 1988 Mar-Apr Vol. 16 Issue 2 Pg. 95-7 ISSN: 0300-8126 [Print] Germany
• PMID: 3372026 (Publication Type: Case Reports, Journal Article)

Chemical References

• Clindamycin
• Methicillin

Topics

• Aged
• Clindamycin (therapeutic use)
• Humans
• Male
• Methicillin
• Penicillin Resistance
• Pneumonia, Staphylococcal (drug therapy)
• Staphylococcal Infections (drug therapy)
• Staphylococcus aureus (drug effects)
• Surgical Wound Infection (drug therapy)