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Risk Factors for Mortality in Denim Sandblasters Silicosis: Selecting Candidate for Lung Transplantation.

AbstractOBJECTIVE:
This study aimed to review the risk factors for silicosis together with survival analysis and a perspective for lung transplantation with data from a single center.
MATERIAL AND METHODS:
We reviewed the medical records of denim sandblasters who were referred to our center between January 2006 and December 2011 and evaluated 219 patients with a history of denim sandblasting with a minimum follow-up period of 5 years until 2016. We analyzed several personal and occupational features, together with functional and radiologic data.
RESULTS:
Of the 219 denim sandblasters, 107 (49%) had been diagnosed with silicosis. In the logistic regression analysis, the duration of exposure was the only independent risk factor for the development of silicosis, indicating a 9% increased risk of silicosis for every month of exposure (p<0.001; odds ratio 1.09; 95% confidence interval 1.050-1.132). Of the patients, 7 (3%) died. A forced expiratory volume in the first second of <44% and a forced vital capacity of <47% were associated with an increased risk of mortality. Mortality was significantly higher in the international labor office category 3 patients, and 5-year survival rates of patients with A, B, and C lung opacities were 88%, 67%, and 25%, respectively.
CONCLUSION:
Silicosis still kills young workers. Severe radiologic involvement and decreased lung volumes are related to mortality, and lung transplantation is the only therapeutic option.
AuthorsTürkan Nadir Öziş, Nur Şafak Alıcı, İbrahim Onur Alıcı, Dilek Ergün, Emine Avcı, Nevin Taci Hoca, Ömer Hınç Yılmaz
JournalTurkish thoracic journal (Turk Thorac J) Vol. 22 Issue 1 Pg. 50-56 (Jan 2021) ISSN: 2149-2530 [Electronic] Turkey
PMID33646104 (Publication Type: Journal Article)

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