[Preclinical results with 15-deoxyspergualin in experimental graft versus host disease].

Abstract

The efficacy of 15-deoxyspergualin (15-DS) was tested in two models of experimental graft versus host disease (GvHD) in mice. In both models, which lead to a hemolytic anemia or to a glomerulonephritis respectively followed by subsequent death of the animals, 15-deoxyspergualin showed good therapeutic effects.

• Authors: G Dickneite, H U Schorlemmer, H H Sedlacek
• Journal: Immunitat und Infektion (Immun Infekt) Vol. 16 Issue 1 Pg. 23-4 (Feb 1988) Germany
• Vernacular Title: Präklinische Untersuchungen mit 15-Deoxyspergualin bei experimenteller Graft-versus-host-Erkrankung (GvHD).
• PMID: 3360464 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Guanidines
• gusperimus

Topics

• Anemia, Hemolytic (etiology, prevention & control)
• Animals
• Antibiotics, Antineoplastic (therapeutic use)
• Disease Models, Animal
• Glomerulonephritis (etiology, prevention & control)
• Graft vs Host Disease (drug therapy)
• Guanidines (therapeutic use)
• Mice
• Mice, Inbred DBA
• Mice, Inbred Strains